Skin Infection Treatment: What Works and What to Know

If your skin is red, swollen, or oozing, you’re likely dealing with an infection. The good news is that most skin infections can be cleared with the right approach. Below we break down the basics, from everyday creams to surprising drug repurposing tricks.

First‑line treatments you can trust

Most doctors start with a topical antibiotic like mupirocin or a short course of oral antibiotics such as cephalexin. These medicines target the bacteria that cause common issues like impetigo, cellulitis, and folliculitis. Apply the cream exactly as instructed—usually twice a day for 5‑7 days—to keep the infection from spreading.

If you’re allergic to penicillin, alternatives like clindamycin or doxycycline work well. Doxycycline has the added perk of being anti‑inflammatory, which can calm the redness faster. Always finish the full prescription, even if the skin looks better early on.

When repurposed drugs step in

Sometimes the usual antibiotics aren’t enough, especially with resistant strains. In those cases, doctors look at older drugs that were made for other illnesses. Hydroxychloroquine, for example, is famous for treating malaria but also helps some chronic skin conditions tied to inflammation.

Another clever repurposing trick involves low‑dose ivermectin, originally an anti‑parasitic. Recent studies show it can kill certain skin bacteria when used in a cream form. While still off‑label, many dermatologists report good outcomes for stubborn cases.

Before trying any repurposed medication, get a clear prescription and discuss potential side effects. These drugs can interact with other medicines, so a quick chat with your pharmacist can save headaches later.

Practical steps to speed up healing

Keep the infected area clean—wash gently with mild soap and water twice a day. Pat dry, don’t rub, because friction can worsen the irritation. Cover with a breathable bandage if the spot is likely to get dirty.

Boost your immune system with plenty of water, balanced meals, and sleep. Vitamin C and zinc support skin repair, so adding a fruit or a handful of nuts won’t hurt.

If the infection isn’t improving after 48‑72 hours, call your doctor. Worsening redness, fever, or spreading rash are signs you need a different antibiotic or a deeper evaluation.

At Repurposed Pills, we track how existing drugs get new life in treating skin infections. Our articles dive into the science behind each repurposed option, so you can stay informed about the latest advances. Knowledge is power—especially when it comes to keeping your skin healthy.